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UCT Prague
Technická 5
166 28 Prague 6 – Dejvice
Identification No.: 60461373
VAT: CZ60461373


Copyright: UCT Prague
Information provided by the Department of Communication.

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The University of Chemistry and Technology, Prague is a natural centre of first-rate study and research in the area of chemistry in Czechia and is one of the country's largest educational and research institutions focused on technical chemistry, chemical and biochemical technologies, material and chemical engineering, food chemistry, and environmental studies.

 

UCT Prague - A challenge that pays off

 

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The University of Chemistry and Technology, Prague consists of four faculties and several other departments

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Faculty of Chemical Technology

101 Department of Inorganic Chemistry    
105 Department of Inorganic Technology    
106 Department of Metals and Corrosion Engineering    
107 Department of Glass and Ceramics    
108 Department of Solid State Chemistry    
110 Department of Organic Chemistry    
111 Department of Organic Technology    
112 Department of Polymers    
126 Department of Solid State Engineering    
141 Laboratory of Inorganic Materials    
143 Department of Informatics and Chemistry    
148 Department of Chemical Technology of Monument Conservation    
150 Dean’s Office of Faculty of Chemical Technology    

Faculty of Environmental Technology

215 Department of Petroleum Technology and Alternative Fuels    
216 Department of Gaseous and Solid Fuels and Air Protection    

217 Department of Water Technology and Environmental Engineering
   
218 Department of Power Engineering    
240 Department of Environmental Chemistry    
241 Department of Sustainability and Product Ecology
251 Dean’s Office of Faculty of Enviromental Technology    

 

Faculty of Food and Biochemical Technology

319 Department of Biotechnology    
320 Department of Biochemistry and Microbiology    
321 Department of Carbohydrates and Cereals    
322 Department of Dairy, Fat and Cosmetics     
323 Department of Food Analysis and Nutrition    
324 Department of Food Preservation    
342 Department of Chemistry of Natural Compounds    
352 Dean’s Office of Faculty of Food and Biochemical Technology    

Faculty of Chemical Engineering

402 Department of Analytical Chemistry    
403 Department of Physical Chemistry    
409 Department of Chemical Engineering    
413 Department of Mathematics (replaced by 446)    
444 Department of Physics and Measurements    
445 Department of Computing and Control Engineering (replaced by 446)    
446 Department of Mathematics, Informatics and Cybernetics
453 Dean’s Office of Faculty of Chemical Engineering    

 

University Research and Education Centres

504 University Centre UCT Prague - Unipetrol    
550 Department of the National Institute of Virology and Bacteriology (NIVB) 
554 Department for the History of the Chemical Industry and Applied Chemistry    
557 BIOMEDREG    
558 Metrology and Testing Laboratory    
559 Prague University Analytical Center    
560 BAFA    
570 Technoparc Kralupy UCT Prague    

The Administration of University Facilities

712 Director´s Office    
713 Finance Department    
721 Operating Department    
723 Sázava Dormitory    
724 Volha Dormitory    
731 Technical Department    
747 Conference Center
748 Recreation facility Jáchymov     
749 Recreation facility Pec p. Sněžkou 
755 Volha Canteen
756 Club Carbon
757 Zikova Canteen
758 Camping site Běstvina

Service Departments for all UCT Prague Faculties

827 Department of Physical Education and Sport    
832 Department of Chemical Education and Humanities    
834 Department of Languages    
837 Department of Economics and Management     

Rector's Offices

929 General Practitioner    
930 Crèche Zkumavka    
938 Department of Internal Auditing    
939 Department of Supervision    
940 Counselling and Career Centre
955 Project Centre
961 Rector's Secretariat    
962 Registrar's Secretariat    
963 Department of Education    
965 Research and Technology Transfer Office    
966 Personnel Department    
968 Records Office     
969 Supplies Department    
971 Finance Department    
972 Department of Safety and Risk Prevention    
974 Department of International Relations    
976 Department of Construction and Maintenance    
977 Department of Building Administration    
979 Department of Communication    
980 Central Laboratories    
990 Computer Centre    
991 Department of Strategic Planning    
992 Hollow Glass Workrooms    
994 Technology Transfer Office    
995 Department of Operation and Technical Services    
996 Department of Public Order    
997 Centre for Information Services
        UCT Library
        UCT Press
   
998 Vice-Rector's without Portfolio Office    




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UCT Prague is a research university primarily focused on technical chemistry, chemical and biochemical technologies, material and chemical engineering, food science, and environmental science. Its cutting-edge facilities and equipment together, with an impressive scientific and research profile, make it an ideal training ground for the managerial, R&D, and public sector leaders of the future.

UCT Prague has four faculties. Its competitive edge lies in its unique “weaving together” of teaching activities with the highest-quality basic and applied research. Across UCT Prague, scientific teams are intensively involved in various national and international cooperative R&D efforts. The Project Centre provides methodological and administrative support to researchers submitting project applications and managing funded projects.

UCT Prague considers the commercialisation of applied research to be an important part of its mission. For that reason, UCT Prague’ss Research and Technology Transfer Office offers researchers support, contributing to extending valourisation of scientific outputs and pursuing the quest for new collaborative partners in applied settings. In 2015, UCT Prague opened Technopark Kralupy, a science and technology hub focused on chemistry for building construction applications, materials engineering, and related fields. The Technopark plays an essential role in UCT Prague’s technology transfer efforts and strategies.

The Research and Technology Transfer Office facilitates internal grants for researchers and students, offers opportunities to compete in prestigious research competitions, and promotes active engagement and participation in student conferences.

UCT Prague is an attractive institution for young scientists and early career researchers, and the Project Centre actively supports hosting and mentoring ECRs, e.g. as part of Marie Skłodowska-Curie Actions. Here, ECRs can apply for a prestigious start-up grant, the Dagmar Procházková Fund, in order to create their own UCT Prague research groups. Postdoctoral fellows at UCT Prague receive extensive international mobility support for broadening their research horizons.

UCT Prague is actively involved in global scientific efforts and is continuously expanding and deepening its collaborations with partners around the world. The basic pillars of these activities include scientific research projects, inter-university cooperation memoranda, and Erasmus+ agreements. UCT Prague additionally creates and accredits joint study programmes with universities abroad.

Paving the way for the European Commission’s HR Excellence in Research Award, UCT Prague is committed to creating collegial working conditions, supporting continuous professional development, and transparent hiring procedures. The Personnel Department co-creates facilities for employees together with the Welcome Centre, which supports employees arriving from abroad, from assisting with the visa process to answering questions about everyday life in Prague. In its determination to be an attractive and welcoming institution for all employees and students, UCT Prague has created a Gender Equality Plan, an executive action initiative.

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UCT Prague has a long tradition of collaborative and cooperative activities, across technological sectors, with other institutions and laboratories, secondary schools, and industrial and international partners - nearly seventy percent of which are located beyond the boundaries of the Czech capital.

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Contact for media

Feel free to contact Department of Comunication with any inquiry. The department will provide contact on University scientific staff.

Main contact person

L Mgr. Michal Janovský
b Michal.Janovsky@vscht.cz
e + 420 220 444 159
e + 420 733 690 543
- Room: A205a

Deputy contact person

D Mgr. Jan Kříž
b Jan2.Kriz@vscht.cz
e +420 220 443 799
: +420 728 831 726
Room A318

Whole team of Department of Comunication


Press releases

 

You can find older press releases in archive.

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This webpage is intended for graduates of UCT Prague. Here you can register in the Alumni database, view defended theses or get copies of your lost or destroyed documents about your studies.

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Counselling and Career Centre UCT Prague

We offer students and graduates counselling, psychological counselling, soft skills workshops and job offers.

 

Alumni Club

The Alumni Club of the UCT Prague, brings together alumni and friends of the University. It strives to create a mutual communication platform between the school, alumni and current students. The club offers alumni meetings and lectures by successful alumni. 

 

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In 2002, refining and petrochemical group Unipetrol launched its collaboration with the University of Chemistry and Technology in Prague (UCT), which culminated in 2015 with the foundation of the University Centre UCT Prague – Unipetrol Litvínov. The Centre is situated right on the premises of Unipetrol’s manufacturing plant in Záluží near Litvínov. It is a unique project in the Czech Republic but also in Europe when a public institution of higher education is located on a commercial production site. It also provides a unique opportunity to use theoretical knowledge in practice, which is what both schools and industrial businesses have wished for many years. The Faculty of Mechanical Engineering of the Czech Technical University (CTU) in Prague has now become another partner of the Centre. It plans to include the instruction of two to three subjects on the site. With the University Centre’s expansion, Unipetrol is increasing the opportunities for university studies in the Ústí Region and helps to build the region’s attractiveness and competitiveness.

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The new name will be University Centre Litvínov UCT – FE CTU – ORLEN Unipetrol (in Czech: Univerzitní centrum Litvínov VŠCHT – FS ČVUT – ORLEN Unipetrol). All three parties agreed on the name when signing a memorandum of cooperation. The University Centre is based in Chempark and is significantly involved in collaboration with the Unipetrol Centre for Research and Education (UniCRE). UniCRE offers students a broad range of possibilities to be engaged in real-life projects. They register 35 undergraduates in three bachelor’s and one follow-up degree programmes. Chempark in Záluží near Litvínov is the largest manufacturing site of the Unipetrol Group with 2,500 employees.

“We are pleased that the foundation of our development has gained another level thanks to the collaboration between the University Centre on our production site and the Faculty of Mechanical Engineering of the Czech Technical University. With this move, we are getting another step forward on the path of the Czech industry to a more intensive combination of theory and practice. With expanded study opportunities in the Ústí Region, we will also contribute to boosting the region’s attractiveness and competitiveness in the Czech Republic,” says Tomasz Wiatrak, Chairman of the Board of Directors of the Unipetrol Group.

“As part of its competences, CTU’s Faculty of Mechanical Engineering has long felt its shared responsibility for the competitiveness of the local industry, hence the entire Czech Republic’s economy, in global markets. We want to prepare enough graduates with appropriate education, offer knowledge with innovation potential for the industry, and build the ecosystems of collaboration with industrial partners actively,” says Michael Valášek, Dean of the Faculty of Mechanical Engineering of the Czech Technical University. He adds: “The memorandum we have signed materialises this approach of the Czech Technical University, which goes well beyond the attitudes of standard universities. The expanded University Centre Litvínov UCT– FE CTU – ORLEN Unipetrol is actually an ecosystem where our role is to transform the knowledge of UCT colleagues into the application in the facilities of Unipetrol, which is our common industrial partner. Of course, the University Centre has a much broader reach, and it will impact the entire segment and region.”

 “Education is the fundamental prerequisite for any future increase in the living standards of any nation. We must educate new experts and managers who will continue the efforts of the current and past generations. As a significant employer and one of the largest companies in the Czech Republic that is part of its critical infrastructure, we are aware of our responsibility and invest in support and promotion of education at all levels. Over five years of existence, a total of 112 students have successfully completed at the University Centre. I am pleased this number will multiply thanks to the new era we are opening right now,” explains Tomáš Herink, a member of the Board of Directors of the Unipetrol Group and a UCT graduate and university pedagogue. 

“The University Centre Litvínov offers university education with an individual approach to students, as is a good tradition of the University of Chemistry and Technology. It is also possible thanks to exceptionally close contacts with the industrial practice of Unipetrol and research-oriented centre, UniCRE. We want to continue developing our activities within the University Centre Litvínov UCT – FE CTU – ORLEN Unipetrol with regard to the requirements of modern industrial firms in the region. We want the centre to be attractive for the prospective students and to offer them education with good prospects on the labour market. I am pleased that the new partnership with FE CTU will not only expand the offer of subjects for students but also contribute to the development of joint research activities that are an integral part of any university environment. For the benefit of all stakeholders, we will work towards the joint submissions of scientific and research projects in the Czech Republic and abroad, including the programme calls of the European Union. As a native of nearby Louny, I am delighted that the University Centre’s expanded collaboration will encourage high-quality education opportunities and drive world-leading applied research in the beautiful, yet historically sorely tried Ústí Region,” says Pavel Matějka, Rector of University of Chemistry and Technology Prague.

  


For more information please contact:

Michal Janovský, 
Phone line: +420 220 444 159
Cell phone: +420 733 690 543
michal.janovsky@vscht.cz

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Prague, 8 September 2020 – The University of Chemistry and Technology, Prague, has new international partners. During a trip to Taiwan last week as member of an official Czech national delegation, UCT Prague Rector Pavel Matějka signed three memoranda for cooperation and international student exchange with National Tsing Hua University (168th place in the US Global World Ranking 2021); National Taipei University of Technology (488th place); and the oldest private institution in Taiwan, Tunghai University.

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In addition to these ceremonial actions, Rector Matějka discussed possibilities for cooperation in the areas of biomedical research and the circular economy with the Industrial Technology Research Institute and established new contacts with Academia Sinica, Taiwan’s equivalent to the Czech Academic of Sciences. Matějka’s agenda also included a meeting with representatives of National CHung Hsing University, UCT’s Prague’s long-time research collaborator. Last but not least, Rector Matějka met with representatives of National Chiao Tung University, who has previously been collaborating with UCT Prague in the field of supramolecular chemistry.

“Cooperation with universities in Taiwan is not new for UCT Prague and we have had very positive experiences both in terms of collaboration on individual research projects and student exchanges. However, personal contacts with the leaders of individual universities and research institutions give this cooperation a new institutional dimension, enabling us to spread this across our faculties, creating favourable circumstances for student exchanges,” Rector Matějka said.

Universities and research institutions in Taiwan have close ties to Taiwan’s advanced IT companies engaged in Industry 4.0 practices, whose products are recognized the world over. “This will undoubtedly contribute to the attractiveness of internships for our students. This cooperation with research institutions in Taiwan is significantly supported by the Economy, Trade, Science, and Research section of the Czech Economic and Cultural Office Taipei,” Rector Matějka said. “Many thanks to Marie Leflerová, head of this section, who ensured maximally effective use of time during this program-intensive visit.” he added.

 


For more information please contact:

Michal Janovský, 
Phone line: +420 220 444 159
Cell phone: +420 733 690 543
michal.janovsky@vscht.cz

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Prague – September 1, 2020:  During the visit to Zentiva on August 27, 2020 in Prague, a government delegation led by Czech Republic's Prime Minister Andrej Babiš met with the representatives of The Parc, The Pharmaceutical Applied Research Centre, and representatives of academic institutions involved in the project.  

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“We discussed The Parc with participating academic institutions and we agreed that our government and the Research, Development and Innovation Council are certainly interested in supporting it. It is important mainly for students, but also science and research in healthcare”, posted Prime Minister Andrej Babis on his twitter account. This marks the beginning of a partnership between both parties who agreed to pursue the discussion in the near future.

The government delegation led by Prime Minister Andrej Babiš also included Minister of Health Adam Vojtěch, epidemiologist and Government Commissioner for Science and Research Roman Prymula and CzechInvest representatives, CEO, Patrik Reichl and Hana Chlebná, Business development manager. The Parc project was introduced by Pavel Šebek, Development Director of Zentiva, Professor František Štěpánek, The Parc´s Scientific Director and Ondřej Dammer, Operational Director of The Parc and Senior scientist in Zentiva, and academic partners of The Parc: Professor Jan Konvalinka, Vice-Rector for Research, Charles University, Prof. Pavel Matějka, Rector, University of Chemistry and Technology and Dr. Zdeněk Hostomský, Director of Institute of Organic Chemistry and Biochemistry, CAS. Zentiva´s team was led by Nick Haggar, CEO Zentiva, Soňa Porubská, General Manager of the Czech Republic and Slovakia, and Martin Albert, Head of New Products.   

“At Zentiva, we are passionate supporters of The Parc that bridges the gap between theoretical Science and what happens in the real life in Pharma. We are very proud of the results and the excellent work this research cluster bring for the development of the next generations of scientists and engineers to make the Czech Republic even stronger in pharmaceutical R&D and manufacturing”, said Nick Haggar, CEO Zentiva.

Initiated by Zentiva, The Parc was created in association with three academic partners: the University of Chemistry and Technology Prague; the Faculty of Science of Charles University; and the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences. This highly successful initiative has brought rising talent together with leading pharmaceutical and academic experts, to accelerate innovation in drug research & development. The Parc provides world-class graduate academic education combined with practical hands-on industrial and business experience under the leadership of scientists, engineers, and managers both from academia and the pharmaceutical industry. 

“The Parc represents a research platform connecting the entire process of drug development from the search for solid forms of active substances, through preformulation experiments, pharmaceutical technologies to clinical testing and production. Currently, 33 doctoral students are participating in this program. Since its inception, 13 students have successfully graduated, 6 of whom joined Zentiva, 2 continue their academic careers and expand The Parc network of pharmaceutical researchers, and 5 graduates work in leading pharmaceutical companies in the Czech Republic and abroad, said the scientific director of The Parc, said Prof. Stepanek

The Parc collaborates with the best universities in the field in Europe and provides students with the opportunity for international research stays and collaborations. Its members also participate in two pan-European projects under the EU Horizon 2020 program. The Parc presented plans for building its research center in Zentiva's industrial park. The new laboratories would enable The Parc further increase scientific output and verification of the academic concepts on a larger pilot scale, which can be directly used for industrial applications. The research center will also provide space for the establishment and development of pharmaceutical start-up companies.

“CzechInvest is delighted to have taken part in the successful development of The Parc since its inception. The project has already demonstrated beneficial outputs from the application of cutting edge expertise and technologies, producing high calibre graduates and a number of patent applications. CzechInvest will work closely with the Government to secure public funding to advance The Parc project’s infrastructure as well as assisting start-ups in furthering their development”, said  Patrik Reichl, CEO CzechInvest.

For more information about The Parc,  Faculty of Science of Charles University, the Institute of Organic Chemistry and Biochemistry of Czech Academy of Sciences , the University of Chemistry and Technology Prague, and Zentiva, please visit the websites.

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UCT Prague together with the water utility Pražské vodovody a kanalizace, a.s. from Veolia group works on development of technologies for the removal of antibiotic-resistant bacteria from sewage sludge and monitors the occurrence of the precursor of COVID-19 in wastewater.

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The current dry episodes create demand for organic matter in agriculture, which increases water retention in the soil. Stabilized sewage sludge can (despite its use as fertilizer) largely satisfy this demand. Newly introduced tightening of legislation for the application of sludge in agriculture concerns the introduction of pathogenic microorganisms, heavy metals, pesticides and drug residues into the soil. However, the risk associated with the spread of antibiotic-resistant bacteria (ARB), which can occur with the application of sludge in agriculture, has not yet been systematically addressed. It is also not clear what technologies can be used to eliminate the presence of ARB.

Monitoring the spread of ARB in the environment has recently received much attention in view of the alarming increase in the number of patients who do not respond to antibiotic treatment, even in relatively common diseases such as pneumonia or tuberculosis. One of the ways in which ARB spreads in the environment is effluents from wastewater treatment plants (WWTPs) and sewage sludge, which is used to fertilize agricultural land. Through agricultural crops, ARB can reach the food chain, endangering the human population.

Several studies have already been published comparing the occurrence of various ARBs in WWTP effluents on a European and global scale, but so far, sufficient information on the situation in the Czech Republic is lacking.

In June of this year, the teams of the University of Chemistry and Technology in Prague and the Prague water utility (PVK a.s.) started the joint ARG Tech project (Technology for removal of antibiotic resistance genes from sewage sludge applied in agriculture), which deals with testing ARB removal efficiency in available sewage sanitation technologies such as thermophilic anaerobic sludge stabilization, thermal hydrolysis, pasteurization, and liming. The aim of the project is to design such parameters of sludge sanitation processes that will ensure the removal of ARB and thus enable the safe use of sludge as an agricultural fertilizer.

In connection with the COVID-19 pandemic, the ARG Tech project was extended to include long-term monitoring of SARS-CoV-2 - the precursor of COVID-19 - in wastewater. In the Prague sewer network, 20 sampling points were selected, which represent various types of settlements such as Prague housing estates, the city center, university dormitories, hospitals or Václav Havel Airport. The presence of the virus will be monitored for two years, in most locations with a two-week interval. We assume that the occurrence of the virus in wastewater will correlate with the spread of the disease in the population, and that this monitoring may contribute to the early detection of the arrival of further waves of the COVID-19 epidemic (not only) in Prague.

 


For more information please contact:

Michal Janovský, 
Phone line: +420 220 444 159
Cell phone: +420 733 690 543
michal.janovsky@vscht.cz

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Prague, June 2, 2020 - Imagine a robot the size of a human cell that is powered remotely and navigated by light. And imagine that this robot can perform mechanically very precise tasks indefinitely (while maintaining the light source) at the level of the microworld. And without the need for any invasive intervention “from the outside.” The possibilities for use in the creation of new materials or manipulation with individual cells in the field of biomedicine are limitless. Ivan Řehoř’s research group at UCT Prague is capable of producing such microrobots. The group’s new discovery, carried out in cooperation with the Czech Academy of Science’s Institute of Organic Chemistry and Biochemistry and Utrecht University, were recently published in the prestigious journal Soft Robotics.

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The ability of robotic manipulation in the past has profoundly changed many sectors of human activity, such as the automotive industry and line production in general. We are taking the first steps towards ability to perform similar tasks on a microscale, that is, at the level of the micrometer, or tens of microns,” said Dr. Ivan Řehoř. In the near future, this could radically change the production of materials, biomedical applications, and other areas, because it will be possible to manipulate individual cells more easily, cheaply, accurately, and safely and, for example, assemble them into larger functional units.

Řehoř’s microrobots are made up of light-responsive hydrogel microparticles. They are produced in a process called stop-flow lithography and they also include gold particles. “If you make a small robot, it cannot carry its own energy source. That’s why our robots are powered remotely by a beam of light. The gold particles effectively capture this light and transform it into heat, the result of the robot’s own movement through repeated contractions of its body,” explained Řehoř, who spent part of his scientific career at Utrecht University in the Netherlands.

Light as a source of movement is not a new idea. But what makes research at UCT Prague exceptional is the very way of control of the robot’s movement. These microrobots crawl on the surface in the simplest possible way: the robots’ bodies simply shrink and expand again. A key role is played by the uneven change of friction between the robot and the ground on which it slides. “This change stems from the complex processes in the robot’s material that take place during its shrinkage and expansion at the molecular level of entanglement and re-unraveling of the individual polymer chains from which it is made. With this, our system is unique and this also allows to use a completely simple system of control and navigation of the robot by only targeting the light bundle,” Řehoř pointed out.

The great advantage of the new microrobots is the low production cost compared to conventional micromanipulation approaches. Current instruments that use the “conversion” of macroscopic movements to the microscale, such as assisted reproduction devices or microsurgery, are very expensive. In addition, they always require a firm connection between the handling location and the external device. “The production price of one robot is quite negligible,” said Dr. Řehoř, adding that his new approach will withstand even the competition from similar approaches to manipulation at the micro level, which typically use a magnetic field instead of light. “Our robot control device is much simpler than those used with the magnetic robots and can be easily built for 500 euros. In addition, we are working on the development of microrobots that could one day be powered by ordinary sunlight and crawl anywhere. But this may really take some time.”

 

 

Links

Research group website: hydrogel.vscht.cz.

Rehor, I.; Maslen, C.; Moerman, P. G.; van Ravensteijn, B. G. P.; van Alst, R.; Groenewold, J.; Eral, H. B.; Kegel, W. K. Photoresponsive Hydrogel Microcrawlers Exploit Friction Hysteresis to Crawl by Reciprocal Actuation. Soft Robot. 2020https://doi.org/10.1089/soro.2019.0169

 


RNDr. Ivan Řehoř, Ph.D. is currently working at UCT Prague’s Department of Chemical Engineering and the Czech Academy of Science’s Institute of Organic Chemistry and Biochemistry (IOCB). He studied inorganic chemistry at Charles University. From 2010-2014, he worked at IOCB. From 2015-2018, he conducted research at Utrecht University with prestigious Marie-Curie Fellowship support. He joined UCT Prague in 2019 as the recipient of the Dagmar Procházková Fund’s initiation grant, which serves to support scientific projects of academic staff with international experience with the expectation that the professional careers of recipients will be connected to UCT Prague. At IOCB, the Purkyně Fellowship supported his research activities.

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Prague, July 10, 2020 – The University of Chemistry and Technology, Prague has received full accreditation for Bachelor’s and Master’s degree programmes in Economics. UCT now ranks among other prestigious Czech and foreign universities which consider this specialisation an integral part of their pedagogical and research activities. In line with its traditional academic disciplines in science and technology, the programmes in economics aim at reaching the highest standard of quality.

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“The outcome of such study is logical - attractive career prospects and deep knowledge will generate the best capital for every student for the future. Study at UCT has fundamentally been and will be challenging, which applies to all the degree programmes including the newly accredited ones”, UCT rector Matějka says.

The degree programmes in Economics and Management (BSc) and Sectoral Management (MSc) will be guaranteed by an experienced team of 60 academics who previously established and implemented similarly focused academic programmes at the MIAS School of Business CTU in Prague.

Applicants interested in the field of economics and management will be given the opportunity to receive an education at the second highest ranked university in the Czech Republic according to QS World University Rankings, to gain an attractive graduate profile sought out by employers, and to undertake further studies at prestigious Czech and foreign universities. The establishment of both degree programmes is officially supported by the Association of Chemical Industry and the Federation of Food and Drink Industries of the Czech Republic among other organisations.

This is not the first time that an economics degree programme has been accredited at UCT as one of the faculties used to bear the word ‘economics’ in its title in the 1960s. Many of its graduates are still employed in top management of large companies and organizations.

Submission of applications for the above-mentioned degree programmes are open from today until August 8 via the portal business.vscht.cz. Applicants with secondary school grade point averages between 1.0- 1.5 will be accepted automatically; all others may take the on-line entrance exam in the following weeks.

The winter term courses begin on September 14, 2020

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The Mycobacterium tuberculosis causes over a million deaths annually. Especially in third-world countries, it is still a severe problem, which may even worsen due to antibiotic resistance. An international team of researchers, together with Dr. Michal H. Kolář from UCT Prague, has now developed new compounds to fight the bacterium, which had cost George Owell or Jane Austen their lives.

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The derivatives of phenothiazine belong to successful drugs. Chlorpromazine, for instance, which is on the World Health Organization List of Essential Medicines, acts on the central nervous system and is used to treat various psychotic disorders. The medical effects of phenothiazine derivatives were discovered in the mid 20th century. Since then, phenothiazine has been used as a lead compound for rational drug design and researchers constantly seek its new analogs with novel modes of action against various diseases. Interestingly, some of the analogs have been shown to inhibit the NDH-2 enzyme involved in the respiratory cycle in the M. tuberculosis.

Surprisingly, a class of phenothiazines with several halogen atoms has been overlooked so far. Now researchers from several universities, including UCT Prague, studied polyhalogenation as a strategy to generate new phenothiazine drugs. Lead by Prof. Tabarrini (Università degli Studi di Perugia, Italy), the team synthesized over twenty polyhalogenated phenothiazines and tested them against M. tuberculosis. They discovered three compounds with stronger antitubercular activity than known molecules. Moreover, their compounds show lower affinity of the receptors of the central nervous system, so they could potentially have lower psychotic side effects.

"Since my postdoctoral stay in Germany, it wasn't really a straightforward path to the phenothiazines," says Dr. Kolář, the co-author of the article published recently in the European Journal of Medicinal Chemistry, and a group leader at the Department of Physical Chemistry, UCT Prague. "We studied something entirely different. We were interested in the interaction between polyhalogenated molecules and a small RNA from HIV. After almost two years we reached a dead end, so we could have either thrown everything into the trash or found another purpose. Luckily, my colleague from Italy got the idea to try the compounds against tuberculosis. And things started moving."

Dr. Kolář performed computer simulations and proposed the first series of compounds (back then for other purposes, though). Then the compounds were optimized to kill the bacterium. The best-performing molecule contains two bromine atoms placed symmetrically on the phenothiazine core. A successful tetrachlorinated derivative was also synthesized.

"We still don't know how exactly the compounds bind to the NDH-2. The situation is even more complicated because the enzyme structure is known in other bacteria but not in the M. tuberculosis," suggests Kolář possible direction of their future research. Although the compounds are far from being used in medical care soon, the knowledge and new principles about polyhalogenation may speed up the hunt for efficient antitubercular drugs.

Original publication:

M. G. Nizi et al.: Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors, Eur. J. Med. Chem. 2020, 201, 112420, https://doi.org/10.1016/j.ejmech.2020.112420

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UCT Prague
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VAT: CZ60461373


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