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Introduction to Supramolecular Chemistry

Lecture Excercise/laboratory
2019, Winter Semester
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Credits 4
Hours per week 2 / 1 / 0
Examination C+Ex
Study Language Czech
Level []
Guarantor prof. Ing. Pavel Lhoták, CSc.
Supplemental electronic materials available at UCT Prague's e-learning

Summary

SUPRAMOLECULAR CHEMISTRY is one of the most important innovations in inorganic/organic chemistry. Classical chemistry is based on the concept of covalent bonds which hold together the millions of currently known compounds. On the other hand, there are many processes in the Nature (e.g. enzyme-substrate interaction, immune response, complex formation, DNA replication etc.) which are enabled by the existence of intermolecular recognition based on the non-covalent interactions. These interactions, albeit much weaker that the covalent bonds, are responsible for reversibility of living processes in organisms, which is a fundamental prerequisite for function of living matter. As the direct study of non-covalent interactions in living organisms is too complicated, many simpler systems have been developed to mimic the biological functions on synthetic models. SUPRAMOLECULAR CHEMISTRY is highly interdisciplinary science dealing with study of basic principles of non-covalent interactions and their use in the design of artificial molecules capable of some function on molecular level - selective complexation, construction of receptors, self-assembly, molecular recognition etc.

Syllabus

1. What is supramolecular chemistry? Introduction and basic definitions. Chemistry of crownethers - complexation of cationts
2. Noncovalent intermolecular interactions
3. Anion complexation
4. Binding of neutral molecules, chiral recognition
5. Modular approach - the coordination chemistry of bipyridines
6. Calix[n]arenes and related macrocycles
7. Cyclodextrins, cucurbiturils, cyclotriveratrylenes
8. Chemistry of fullerenes, carbon nanotubes and other carbon allotropes
9. Dendrimers
10. The evaluation of the complexation ability - complexation constants
11. Self-assembly
12. Topological isomers (rotaxanes, catenanes, knotanes), nanomachines
13. Liquid crystals
14. Surfactants and interfacial ordering

Literature

R: Jonathan W. Steed, Jerry L. Atwood: Supramolecular Chemistry, 2nd Edition, Wiley 2009. 9780470512340
A: Beer P. D., Gale P. A., Smith D. K.: Supramolecular Chemistry, Oxford Chemistry Primers, Oxford University Press 1999. 0198504470
A: Diderich F., Stang P. J., Tykwinski R. R. (Eds.): Modern Supramolecular Chemistry, Wiley 2008, ISBN: 978-3-527-31826-1.
A: Lhoták P., Stibor I.: Molekulární Design; vysokoškolská skripta, vydavatelství VŠCHT Praha, 1997. 8070802952
A: kolektiv autorů: Supramolekulární chemie I, Cyklus Organická Chemie, svazek 29, 2004, ÚOCHB Praha. 8086241211
A: kolektiv autorů: Supramolekulární chemie II, Cyklus Organická Chemie, Svazek. 30, UOCHB AV ČR Praha, 2005. 8086241270

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