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Biophysical Chemistry

Lecture Excercise/laboratory
2019, Summer Semester
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Credits 3
Hours per week 2 / 0 / 0
Examination Ex
Study Language Czech
Level []
Guarantor Ing. Michaela Marková, Ph.D.
Ing. Zita Purkrtová, Ph.D.

Summary

The lectures are focused on description of physical-chemical aspects of biological systems and use of physical-chemical terms to describe and solve the problems in biological systems. Students will have an overview of the most important concepts and methodology of modern biophysical chemistry as well as structural methods for description of biomacromolecules.

Syllabus

1. Position of biophysical chemistry in the system of natural science
2. Bioenergetics I
3. Bioenergetics II (non-equilibrium thermodynamics)
4. The importance of noncovalent interactions for biological systems
5. The general characteristics of protein structure
6. Methods of kinetics measurement of biological processes
7. Pharmacokinetics
8. Structure and function of biological membranes
9. Biological processes associated with membranes: biochemistry of vision, electron transport chain and photosynthesis
10. Electrochemical processes in biological systems
11. The use of spectrophotometry in biochemical laboratory
12. The use of radiochemistry for the study of biological processes
13. Methods for the study of protein structure I: NMR and X-ray crystallography
14. Methods for the study of protein structure II: circular dichroism and fluorescence spectroscopy

Literature

R: Atkins P.,de Paula J., Physical Chemistry for the Life Sciences, Oxford University Press, 2011, 978-0-19-956428-6
R: Bergethon P.R., The Physical Basis of Biochemistry, Springer-Verlag New York Inc., 1998, 0-387-98262-0
A: Nelson D.L., Cox M.M., Lehninger Principles of Biochemistry, W.H.Freeman, 2008, 978-0716771081

VŠCHT Praha
Technická 5
166 28 Praha 6 – Dejvice
IČO: 60461373
DIČ: CZ60461373

Datová schránka: sp4j9ch

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