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Molecular mechanisms of bacterial virulence

Lecture Excercise/laboratory
2019, Summer Semester
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Credits 3
Hours per week 2 / 0 / 0
Examination Ex
Study Language Czech
Level []
Guarantor prof. Ing. Peter Šebo, CSc.

Summary

The course deals with molecular mechanisms of host-pathogen interactions. Upon recapitulation of the basic
mechanisms of mammalian immune system function, the lectures will focus on genetic basis and regulation
mechanisms underlying virulence of bacterial pathogens. Molecular details of action of major virulence factors,
such as adhesins, toxins, complement resistance and immunomodulatory substances will be discussed. Action of
virulence factors will be discussed from the systemic context of the entire host organism down to the level of
biology and physiology of cells of the immune system. Principles of host-pathogen interactions will then be
analyzed using selected examples of major human pathogens and bacterial infections.

Syllabus

1. Molecular mechanisms of anti-infectious immunity
2. Classes and mechanisms of action of bacterial virulence factors
3. Genetic equipment and gene expression regulation of bacterial pathogens
4. Experimental/animal systems for identification of virulence genes and for analysis of host-pathogen interactions
5. Protective mechanisms enabling bacteria to overcome innate and fool adaptive immunity
6. Cell biology and mechanisms of bacterial toxin action, intracellular bacterial pathogens
7. Vaccines as tools for protection from infection, modulation of host response and immunotherapy
8. Antibiotics as anti-infectious therapeutics and resistance to antibiotics
9. Intestinal microflora, commensals - the human microbiome
10. Most studied bacterial pathogens - an introductory overview:
Corynebacterium diphteriae, Streptococcus pyogenes a Staphylococcus aureus
11. Most studied bacterial pathogens:
Clostridium botulinum/perfringens/tetani, B. cereus, Helicobacter pylori
12. Most studied bacterial pathogens:
Ricketsia, Fracisella, Coxiella, Yersinia, Salmonella, Shigella,
13. Most studied bacterial pathogens:
Campylobacter jejuni, Vibrio cholerae, Escherichia coli - EPEC, ETEC, UPEC, NMEC
14. Most studied bacterial pathogens:
Bordetella, Mycobacterium, Neisseria, Listeria, Borelia, Mycoplasma, Chlamydia

Literature

R:Salyers A.A., Whitt D.D.: Bacterial Pathogenesis: A Molecular Approach, 2007 ASM Press, 978-1555811716
R:Janeway's Immunobiology, Seventh Edition (Immunobiology: The Immune System (Janeway), 2007, Garland Science, 978-0815341239
A:Goering R., Dockrell H., Roitt I., et al.: Mims' Medical Microbiology, 2007, ELSEVIER, 9780323044752

VŠCHT Praha
Technická 5
166 28 Praha 6 – Dejvice
IČO: 60461373
DIČ: CZ60461373

Datová schránka: sp4j9ch

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