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Obnovit | RAW

Labelled Compounds

Lecture Excercise/laboratory
2020, Summer Semester
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Credits 3
Hours per week 2 / 0 / 0
Examination Ex
Study Language Czech
Level []
Guarantor doc. Ing. Libor Havlíček, CSc.

Summary

The course covers the potential of application of isotopically (using stable as well as radioactive isotope) labeled compounds in chemistry, biology and medicine with special aspects of this discipline (synthesis in ng to mg scale, nomenclature, radiolysis, isotopic effect, hygiene of ionizing radiation)

Syllabus

1. Definitions of concepts and quantities in the field of labeled compounds (LC), historical overview, importance of LC, intersections with other disciplines, literature
2. Types of radioactive transformations, kinetics of radioactive transformations, interaction of ionizing radiation (IoR) with matter, other physical principles in LC
3. Dosimetry of IoR (detectors: ionizing, scintillating, integral dosimetry methods)
4. Principles of IoR hygiene. Definition of quantities, basic knowledge of IoR effects on molecule, cell, and organism level, hygiene findings, IoR effects
5. Protection against IoR, LNT basis, ALARA access, lesson from serious nuclear disasters
6. Radio iodine, designation for immune chemical determinations (RIA, IRMA, REA, RRA, FPIA, …)
7. Specialties of LC chemistry (isotopic effect, nomenclature of LC, LC stability, specialties resulting from micro scale synthesis in mg to ng)
8. Overview of application of LC, equivalency of chemical bonds, tautomery, reaction mechanisms, biochemical pathways, internal enzyme transfer, metabolic turns, receptor study, drug development)
9. Hydrogen isotopes labeled compounds. Properties of [3H]-compounds, their synthesis
10. 14C nuclide labeled compounds, 32P or 33P nuclide labeled compounds
11. Labeling with stable nuclides (2H, 13C). Application areas, requirements, synthesis
12. Nuclear medicine - diagnostics (functional diagnostics, "ideal emitter", pure gamma, positron tomography, PET, "shorts", therapy
13. Labeled compounds analysis
14. Chemistry of LC of selected structures (peptides, …)

Literature

R: Navrátil O., Hála J., Kopunec R., Macášek F., Mikulaj V., Lešetický L. Nuclear chemistry, Academia, Praha 1992.
A: Evans E. A., Oldham K. G.: Radiochemicals in Biomedicinal Research , John Wiley and Sons
A: Evans E. A., Tritium and its compounds, Butterworths, 2. ed.
A: Murray A., Williams D.L.: Organ. Syntheses with Isotopes
A: Donald G.: Syntheses with Stable Isotopes
A: Thomas A. F.: Deuterium Labeling in Organic Chemistry

VŠCHT Praha
Technická 5
166 28 Praha 6 – Dejvice
IČO: 60461373
DIČ: CZ60461373

Datová schránka: sp4j9ch

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